Medications are prescribed for many reasons, usually for labeled indications but other times off-label. Knowing why medications are prescribed is essential to help understand the continued need for therapy as well as to determine payment responsibility in this time of Medicare Part D risk.
Namenda (memantine) is well known for its labeled use in treating cognitive decline in patients with moderate to severe Alzheimer's disease. However, its off-label, and potentially related, uses may be less known; for example in managing symptoms such as those in vascular dementia. Recently is has also been used off-label to prevent cognitive decline in patients receiving Whole Brain Radiation Therapy (WBRT)1–2.